Abstract
Aims and objectives: Statins have been proposed as potentially useful agents for modulating the host response in COVID-19. However, solid evidence-based recommendations are still lacking. Our aim was to study the association between statin use and clinical outcomes in a large cohort of hospitalized patients with SARS-CoV-2 infection, as well as the specific consequences of chronic treatment withdrawal during hospital admission.
Material and methods: Retrospective observational study including 2191 hospitalized patients with confirmed SARS-CoV-2 infection.
Results: Mean age was 68.0±17.8 years and 597 (27.3%) patients died during follow-up. A total of 827 patients (37.7% of the whole sample), received chronic treatment with statins. Even though they underwent more frequent admissions in critical care units, chronic treatment with statins was not independently associated with all-cause mortality [HR 0.95 (0.72-1.25)]. During the whole hospital admission, 371 patients (16.9%) received at least one dose of statin. Although these patients had a significantly worse clinical profile, both treatment with statins during admission [HR 1.03 (0.78-1.35)] and withdrawal of chronic statin treatment [HR 1.01 (0.78-1.30)] showed a neutral effect in mortality. However, patients treated with statins presented more frequently hepatic cytolysis, rhabdomyolysis and thrombotic/hemorrhagic events.
Conclusions: In this large cohort of hospitalized COVID-19 patients, statins were not independently associated with all-cause mortality during follow-up. Clinically relevant statin-associated adverse effects should be carefully monitored during hospital admission.
Keywords: Adverse effects; COVID-19; Efectos adversos; Estatinas; Morbidity; Morbilidad; Mortalidad; Mortality; Retirada medicación; Statins; Treatment withdrawal.
【저자키워드】 COVID-19, Mortality, adverse effects, morbidity, statins, Mortalidad, Efectos adversos, Estatinas, Morbilidad, Retirada medicación, Treatment withdrawal., 【초록키워드】 Treatment, Critical care, SARS-COV-2 infection, host response, Withdrawal, Clinical outcome, Patient, statin, age, large cohort, Hospital admission, Follow-up, Admission, association, dose, Neutral, adverse effect, Adverse, hospitalized COVID-19 patients, all-cause mortality, material, whole sample, recommendation, consequence, significantly, events, hospitalized patient, modulating, patients died, patients treated, 【제목키워드】 Treatment, influence, cohort of patient,