Abstract
Objectives: Information on how COVID-19 affects people living with HIV (PLHIV) remains scarce.
Methods: An observational study was conducted in four public hospitals in Madrid. All HIV patients with confirmed or suspected COVID-19 were included and compared with COVID-19 patients without HIV infection.
Results: Sixty-three patients with HIV infection and confirmed or suspected COVID-19 were analyzed. The median age was 46 years (IQR: 37-56 years), and 88.9% were men. The median duration of HIV infection was 10.8 years (IQR: 6.5-16.8 years), and 96.8% were on antiretroviral therapy. 84.1% had previous comorbidities. The most common symptoms were fever (66.1%), cough (66.1%) and dyspnea (46.8%). Pneumonia was found in 47.5%, 28.6% of patients had severe disease, and 32.3% were admitted to hospital. The ICU admission rate and the mortality rate were both 3.17%. A significant association was observed between age, arterial hypertension, overweight, and diabetes mellitus and the severity of COVID-19. No association was observed between HIV-related factors and the severity of COVID-19. The rate of COVID-19 in HIV-patients was 1.68%. Similar hospitalization (31.74% vs 32.57%) and ICU admission (3.17% vs 2%) rates were observed with non-HIV infected patients. A lower mortality rate during hospitalization (10% vs 21.37%) and a lower global mortality rate (3.17% vs 6.96%) were also observed.
Conclusions: Established poor prognostic factors for COVID-19 patients, such as age and comorbidities, remain the main determinants for PLHIV. Neither the HIV severity nor the type of ARV treatment seem to influence the outcome of COVID-19. Large prospective cohorts are needed in order to establish the differences between HIV-positive and HIV-negative patients.
Keywords: COVID-19; HIV; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, HIV, 【초록키워드】 Treatment, SARS-CoV-2, Hospitalization, severity, hospital, Infection, Comorbidities, Diabetes Mellitus, Symptom, outcome, cough, severity of COVID-19, Fever, Antiretroviral therapy, Dyspnea, Patient, ICU admission, age, mortality rate, prospective cohort, patients, COVID-19 patients, HIV infection, association, severe disease, Prognostic factor, Arterial hypertension, determinant, Factor, infected patients, HIV-negative, median age, lower mortality, PLHIV, Affect, Public Hospital, men, ARV, analyzed, conducted, median, with HIV, HIV patient, global mortality, patients with HIV, with COVID-19, 【제목키워드】 multicenter,