Abstract
Background: COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a positive effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, severity, and inflammatory factors in patients with COVID-19.
Methods: Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days.
Results: Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (P value < 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (P value 025).
Conclusion: The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indices, including biochemical and clinical indices.
Trial registration: Iranian Registry of Clinical Trials IRCT20121216011763N46 . 2020-10-31.
Keywords: COVID-19; Clinical symptoms; Clinical trial; Curcumin; Piperine.
【저자키워드】 COVID-19, clinical trial, Curcumin, Clinical symptoms, Piperine., 【초록키워드】 Efficacy, Kidney function, COVID-19 pandemic, severity, CRP, cough, sputum, headache, COVID-19 complications, Protein, Health, clinical, complete blood count, Dyspnea, Health status, Placebo, registry, medication, disease, parameters, Outpatient, liver enzymes, blood glucose, p value, piperine, anti-inflammatory agent, sore throat, two groups, biochemical, placebo group, dry cough, muscular pain, weakness, positive, Inflammatory factor, Affect, effective, Randomly, significantly, the disease, approved, changes in, reduce, receive, creating, not significantly different, patients with COVID-19, with COVID-19, 【제목키워드】 Efficacy, severity, Randomized, placebo-controlled trial, double-blind, Inflammatory factor,