Abstract
Left ventricular global longitudinal strain (LVGLS) from two-dimensional speckle-tracking echocardiography (2D-STE) provides a more accurate estimation of subclinical myocardial dysfunction. In patients with COVID-19, elevated high sensitive troponin (hs-TnI) levels are frequent independent from the underlying cardiovascular disease. However, the relationship between high troponin levels and LVGLS in such patients remains unknown. We aimed to investigate the relation between troponin levels and LVGLS values in patients with COVID-19. A total of thirty-eight patients diagnosed with COVID-19 pneumonia who underwent echocardiography examination within the first week of hospital admission were enrolled in our study. Patients were divided into two groups according to their hs-TnI levels. Conventional left venticular (LV) function parameters, including ejection fraction, LV diastolic and systolic volumes were obtained and LVGLS was determined using 2D-STE. Frequency of hypertension, diabetes mellitus and current smoking were similar among groups. Compared with the patients in the negative troponin group, those in the positive troponin group were more likely to have a higher age; higher levels of D-dimer, C-reactive protein and ferritin; higher need for high-flow oxygen, invasive mechanical ventilation therapy or both; and a higher number of intensive care unit admissions. There was no statistically significant difference in LVGLS and ejection fraction values between the two groups.(- 18.5 ± 2.9, – 19.8 ± 2.8, p = 0.19; 55.2 ± 9.9, 59.5 ± 5.9, p = 0.11 respectively). Despite troponin increase is highly related to in-hospital adverse events; no relevance was found between troponin increase and LVGLS values of COVID-19 patients.
Keywords: 2D speckle tracking echocardiography; COVID-19; High sensitive troponin; Left ventricular global longitudinal strain.
【저자키워드】 COVID-19, 2D speckle tracking echocardiography, High sensitive troponin, Left ventricular global longitudinal strain., 【초록키워드】 therapy, intensive care, Pneumonia, Diabetes Mellitus, C-reactive protein, cardiovascular disease, D-dimer, smoking, hypertension, Patient, Hospital admission, parameters, COVID-19 patients, Invasive mechanical ventilation, Myocardial dysfunction, In-hospital, High-flow oxygen, Volume, Admissions, two-dimensional, Ejection fraction, statistically significant difference, hs-TNI, positive, left, independent, diastolic, enrolled, the patient, elevated, provide, was determined, two group, groups, Conventional, diagnosed with COVID-19, patients with COVID-19, troponin level, ventricular, 【제목키워드】 Pneumonia, patients hospitalized, troponin level, ventricular, with COVID-19,