Abstract
Background: The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding to angiotensin-converting enzyme 2 (ACE2) and activity of the RAAS may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19.
Methods: In this prospective single-center study, we determined the serum levels of ACE2, angiotensin II, and aldosterone in patients with COVID-19 compared with control patients presenting with similar symptoms in the emergency unit.
Results: We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms, and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups.
Conclusions: In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19.
Clinical trials registration: Trial Number DRKS00021206.
Keywords: ACE2; COVID-19; SARS-CoV-2; aldosterone; angiotensin II; blood pressure; hypertension.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, hypertension, aldosterone, Angiotensin II, blood pressure, 【초록키워드】 coronavirus disease, coronavirus, Trial, SARS-COV-2 infection, susceptibility, Symptom, outcome, hypertension, angiotensin-converting enzyme 2, Symptoms, serum, Characteristics, clinical, Patient, RAAS, Potassium, patients, Blood, binding, Evidence, Concentration, host cell, acute respiratory syndrome, number, control group, Serum level, single-center study, positive, serum sample, parameter, Affect, not differ, analyzed, presenting, baseline, control patient, in both groups, patients with COVID-19, the SARS-CoV-2, 【제목키워드】 Level,