Comparative analysis between the use of renin-angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection

Published on
Journal: Medicina clínica
[저자] Jorge Martínez-Del Río, Jesús Piqueras-Flores, Patricia Nieto-Sandoval Martín de la Sierra, Martín Negreira-Caamaño, Daniel Águila-Gordo, Cristina Mateo-Gómez, Daniel Salas-Bravo, Marta Rodríguez-Martínez
[Category] SARS, 임상,
PMC URL    [DOI] 10.1016/j.medcli.2020.07.004    
[Article Type] Observational Study
[Source] PMC

Abstract
Introduction: Hypertension has been associated with worse outcomes in patients with COVID-19 infection, so concerns have been raised about the possibility that inhibitors of the renin-angiotensin system (RAS) could influence the prognosis of these patients.
Methods: This is an observational study of 921 consecutive patients admitted with COVID-19 respiratory infection to Hospital General Universitario Ciudad Real from March 1 to April 30, 2020. Following data were collected including patient demographic information, medical history, clinical characteristics, laboratory data, therapeutic interventions during the hospitalization and clinical outcomes.
Results: The mean age was 78years, and 59.2% of patients had a history of hypertension. Patients with previous treatment with RAS inhibitor (42.4%) showed lower risk of the primary composite endpoint (mortality or need for invasive mechanical ventilation). Treatment with RAS inhibitor (both outpatient treatment and during hospitalization) had neither effect on mortality nor need for invasive ventilation. There were no differences in time-to-event analysis between groups.
Conclusions: RAS inhibitor treatment prior to admission in patients with COVID-19 respiratory infection was associated with lower risk of the primary composite endpoint and did not show neither impact on mortality nor need for invasive mechanical ventilation, even if these drugs were prescribed during hospitalization.
Keywords: ACEI; ARA2; ARB; COVID-19; IECA.

All Keywords
【저자키워드】 COVID-19, ARB, ACEi, ARA2, IECA., 【초록키워드】 Treatment, Mortality, Prognosis, Hospitalization, Clinical characteristics, Infection, drug, outcome, hypertension, invasive ventilation, RAS, clinical outcomes, renin-angiotensin system, respiratory infection, Patient, age, inhibitor, information, Admission, patients, Invasive mechanical ventilation, no difference, laboratory data, lower risk, therapeutic intervention, primary composite endpoint, time-to-event analysis, collected, raised, groups, consecutive patient, patients with COVID-19, with COVID-19, 【제목키워드】 Clinical outcome, renin-angiotensin system, respiratory infection, Comparative analysis, antagonist, hospitalized patient, with COVID-19,