Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics

노카티아신 I 유사체: 새로운 반합성 티아졸 펩타이드 항생제의 합성, 시험관 내 및 생체 내 생물학적 활성

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Journal: Bioorganic & Medicinal Chemistry Letters
[저자] B. Narasimhulu Naidu, Margaret E. Sorenson, Yunhui Zhang, Oak K. Kim, John D. Matiskella, John A. Wichtowski, Timothy P. Connolly, Wenying Li, Kin S. Lam, Joanne J. Bronson, Michael J. Pucci, Junius M. Clark, Yasutsugu Ueda
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1016/j.bmcl.2004.08.058    
[Article Type] journal-article
[Source] pubmed

Several nocathiacin I analogues (4-35) were synthesized and evaluated for their antibacterial activity. Most of these semi-synthetic analogues retained very good in vitro and in vivo antibacterial activity of 1.

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