Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives

O-치환된 노카티아신 I 유도체의 합성과 항균 활성

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Journal: Bioorganic & Medicinal Chemistry Letters
[저자] B.Narasimhulu Naidu, Margaret E Sorenson, Thomas Hudyma, Xiaofan Zheng, Yunhui Zhang, Joanne J Bronson, Michael J Pucci, Junius M Clark, Yasutsugu Ueda
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1016/j.bmcl.2004.04.102    
[Article Type] journal-article
[Source] pubmed

The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity.

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