Peptide deformylase inhibitors with activity against respiratory tract pathogens

호흡기 감염병원체에 대한 활성을 가진 펩타이드 탈포름화효소 억제제

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Journal: Bioorganic & Medicinal Chemistry Letters
[저자] Stephen P East, R.Paul Beckett, Daniel C Brookings, John M Clements, Sheila Doel, Kenneth Keavey, Gilles Pain, Helen K Smith, Wayne Thomas, Alison J Thompson, Richard S Todd, Mark Whittaker
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1016/j.bmcl.2003.10.013    
[Article Type] journal-article
[Source] pubmed

A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3′ amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.

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