Abstract
Inflammation has been believed to contribute to coronavirus disease 2019 (COVID-19). Risk factors for death of COVID-19 pneumonia have not yet been well established.In this retrospective cohort study, we included the deceased patients in COVID-19 specialized ICU with laboratory-confirmed COVID-19 from Guanggu hospital area of Tongji Hospital from February 8th to March 30th. Demographic, clinical, laboratory, and outcome data were extracted from electronic medical records using a standard data collection form. We used Spearman rank correlation and Cox regression analysis to explore the risk factors associated with in-hospital death, especially the association between inflammatory cytokines and death.A total of 205 severe/critical COVID-19 pneumonia patients were admitted in the COVID-19 specialized ICU and 75 deceased patients were included in the final analysis. The median age of the deceasing patients was 70 years (IQR 65-79). The common symptoms were fever (78.9%), cough (70.4%), and expectoration (39.4%). The BNP and CRP levels were far beyond the normal reference range. In the Spearman rank correlation analysis, IL-8 was found to be significantly associated with the time from onset to death (rs= -0.30, P = .034) and that from admission to death (rs= -0.32, P = .019). Cox regression showed after adjusting age and sex, IL-8 levels were still significantly associated with the time from onset to death (P = .003) and that from admission to death (P = .01).IL-8 levels were associated with in-hospital death in severe/critical COVID-19 patients, which could help clinicians to identify patients with high risk of death at an early stage.
【초록키워드】 COVID-19, coronavirus disease, Pneumonia, hospital, Symptom, outcome, risk factor, cough, ICU, Laboratory, Fever, Patient, death, IL-8, demographic, Admission, early stage, Inflammatory cytokine, COVID-19 patients, association, BNP, Analysis, Cox regression, Deceased, high risk, In-hospital death, retrospective cohort study, Factor, clinician, median age, Cox regression analysis, help, Final, Tongji Hospital, CRP level, laboratory-confirmed, Spearman rank correlation, electronic medical record, identify, significantly, contribute, age and sex, COVID-19 pneumonia patient, IQR, 【제목키워드】 death, IL-8, Critical, Prognostic value, patients with COVID-19,