Abstract
Background/aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that utilized up-to-date data on the South Korean population provided by the Korean National Health Insurance System. Of the 62,909 patients with hypertension or heart failure tested for COVID-19, there were 1,644 (2.6%) confirmed cases. After case-control matching, multivariable-adjusted conditional logistic regression analysis was performed.
Results: Comparison between patients exposed to RAAS inhibitors and those not exposed to RAAS inhibitors revealed that the adjusted odds ratio (OR) and 95% confidence interval (CI) for COVID-19 infection and death were 0.981 (95% CI, 0.849 to 1.135) and 0.875 (95% CI, 0.548 to 1.396), respectively. Subgroup analysis for the major confounders, age and region of diagnosis, resulted in OR of 0.912 (95% CI, 0.751 to 1.108) and 0.942 (95% CI, 0.791 to 1.121), respectively.
Conclusion: The present study demonstrated no evidence of association between RAAS inhibitor exposure and risk and severity of COVID-19.
Keywords: COVID-19; Heart failure; Hypertension; Renin-angiotensin system; Republic of Korea.
【저자키워드】 COVID-19, hypertension, renin-angiotensin system, heart failure, Republic of Korea, 【초록키워드】 coronavirus disease, pandemic, Diagnosis, risk, COVID-19 infection, severity of COVID-19, heart, Patient, death, Case-control, RAAS, age, inhibitor, case-control study, Korean, association, Evidence, Analysis, insurance, adjusted odds ratio, Logistic regression analysis, 95% CI, 95% confidence interval, confirmed cases, confounders, South, System, tested, performed, provided, was performed, demonstrated, 【제목키워드】 coronavirus disease, inhibitor, South Korea, association,