Abstract
Objective: A major coronavirus disease 2019 (COVID-19) outbreak occurred in Northeastern France in spring 2020. This single-center retrospective observational cohort study aimed to compare patients with severe COVID-19 and those with non-severe COVID-19 (survivors vs. non-survivors, ICU patients vs. non-ICU patients) and to describe extrapulmonary complications.
Patients and methods: We included all patients with a confirmed diagnosis of COVID-19 admitted to Colmar Hospital in March 2020.
Results: We examined 600 patients (median age 71.09 years; median body mass index: 26.9 kg/m 2 ); 57.7% were males, 86.3% had at least one comorbidity, 153 (25.5%) required ICU hospitalization, and 115 (19.1%) died. Baseline independent factors associated with death were older age (>75 vs. ≤75 years), male sex, oxygen supply, chronic neurological, renal, and pulmonary diseases, diabetes, cancer, low platelet and hemoglobin counts, and high levels of C-reactive protein (CRP) and serum creatinine. Factors associated with ICU hospitalization were age <75 years, oxygen supply, chronic pulmonary disease, absence of dementia, and high levels of CRP, hemoglobin, and serum creatinine. Among the 600 patients, 80 (13.3%) had an acute renal injury, 33 (5.5%) had a cardiovascular event, 27 (4.5%) had an acute liver injury, 24 (4%) had venous thromboembolism, eight (1.3%) had a neurological event, five (0.8%) had rhabdomyolysis, and one had acute pancreatitis. Most extrapulmonary complications occurred in ICU patients.
Conclusion: This study highlighted the main risk factors for ICU hospitalization and death caused by severe COVID-19 and the frequency of numerous extrapulmonary complications in France.
Keywords: COVID-19; Extrapulmonary COVID-19; Mortality; Outcome; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, outcome, Extrapulmonary COVID-19, 【초록키워드】 SARS-CoV-2, severe COVID-19, Hospitalization, Cancer, Comorbidity, CRP, diabetes, risk factor, Venous Thromboembolism, ICU, Dementia, outbreak, Patient, Older age, death, Platelet, Complication, France, complications, age, ICU Patients, hemoglobin, disease, patients, retrospective, Frequency, Male sex, pulmonary diseases, neurological, Extrapulmonary, C-reactive protein (CRP, serum creatinine, Observational cohort study, Non-survivors, Factor, Acute liver injury, oxygen supply, median age, acute renal injury, chronic pulmonary disease, single-center, non-ICU patients, renal, MOST, FIVE, ICU patient, males, independent, occurred, examined, caused, died, required, eight, median, absence, diagnosis of COVID-19, major coronavirus, 【제목키워드】 Hospitalization, ICU, Complication, COVID-19 patient,