A series of 2(Z)-2-Benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase

2(Z)-2-벤질리덴-6,7-디하이드록시벤조퓨란-3[2H]-온의 일련의 화합물이 코리즘산 합성효소 억제제로 작용한다.

Published on
Journal: Bioorganic & Medicinal Chemistry Letters
[저자] Michael G Thomas, Chris Lawson, Nigel M Allanson, Bruce W Leslie, Joanna R Bottomley, Andrew McBride, Oyinkan A Olusanya
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1016/s0960-894x(02)00957-5    
[Article Type] journal-article
[Source] pubmed

A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2′-hydroxy-4′-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.

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