Abstract
Limited data are available on thromboembolic events (TEEs) and mortality in outpatients with coronavirus disease 2019 (COVID-19). This retrospective, observational cohort study identified non-hospitalized COVID-19 outpatients (01/21/2020-01/07/2021) using de-identified Optum ® COVID-19 Electronic Health Records data. Patient characteristics, occurrence of TEEs, all-cause mortality, and anticoagulant or thrombolytic medication use were evaluated. Of 1,246,067 patients with COVID-19 diagnosis, 141 471 met entry criteria. Mean (standard deviation [SD]) age was 46.1 (17.2) years, 56.8% were female, 72.9% Caucasian, 11.2% African American, and 11.1% Hispanic. Comorbidity burden was low (mean [SD] Quan-Charlson comorbidity index score of 0.43 [1.10]); however, of those with body mass index data, half were obese. During the follow-up period, a TEE occurred in 1.4%, with the proportion of patients with ischemic stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism being similar (approximately 0.4% each). All-cause mortality was 0.7%. Medications included corticosteroids (13.7%), anticoagulants (4.9%), and antiplatelets (2.9%). Overall, in this large cohort analysis, certain demographic and clinical characteristics of patients who experienced TEEs were identified and may help guide management decisions and future clinical trials for COVID-19 outpatients.
Keywords: COVID-19; anticoagulation; risk factors; thromboembolism; thrombosis.
【저자키워드】 COVID-19, Risk factors, anticoagulation, Thromboembolism, thrombosis., 【초록키워드】 Corticosteroid, coronavirus disease, clinical trial, Mortality, thrombosis, Clinical characteristics, stroke, Diagnosis, Comorbidity, risk, body mass index, Characteristics, management, female, Patient, age, large cohort, Myocardial infarction, medication, African American, Hispanic, Anticoagulant, Outpatient, retrospective, Analysis, antiplatelet, criteria, Observational cohort study, Standard deviation, follow-up period, all-cause mortality, obese, help, Record, COVID-19 outpatients, Thromboembolic event, Occurrence, occurred, proportion, evaluated, COVID-19 outpatient, Limited, patients with COVID-19, 【제목키워드】 Outpatient, the United State,