Abstract
Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
Keywords: CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA.
【저자키워드】 COVID-19, SARS-CoV-2, T cells, intensive care unit, CD4-to-CD8 ratio, TEMRA., 【초록키워드】 Treatment, immune response, Mortality, intensive care, severe COVID-19, Intervention, ICU, memory, T cell, ROC, Patient, predictor, Admission, Care, CD8+ T cell, marker, Frequency, Analysis, Immune cell, COVID-19 patient, individual, circulating, Kaplan-Meier, significantly lower, TEMRA, ICU patient, resulting, conducted, demonstrated, 【제목키워드】 susceptible, identify,