Abstract
Objectives: To determine whether altered mental status (AMS) as a presenting symptom in older adults with COVID-19 is independently associated with adverse outcomes.
Methods: A retrospective single center observational study of admitted patients (n = 421) age greater than 60 and a positive COVID-19 test. Outcomes included mortality, intubation, acute respiratory distress syndrome, acute kidney injury, and acute cardiac injury. Multivariate regression analysis was used to determine if presenting with AMS was associated with adverse outcomes.
Results: There was an increased risk of mortality (RR 1.29, 95% CI 1.05-1.57), intubation (RR 1.52, 95% CI 1.09-2.12) and AKI (RR 1.42, 95% CI 1.13-1.78) in patients that presented with AMS.
Conclusions: During a global pandemic, prognostic indicators are vital to help guide the clinical course of patients, reduce healthcare cost, and preserve life. Our study suggests that AMS can play a major role in diagnostic algorithms in older adults with COVID-19.
Keywords: AKI; AMS; COVID-19; Geriatrics; intubation; mortality; pandemic.
【저자키워드】 COVID-19, Mortality, intubation, pandemic., Geriatrics, AKI, AMS, 【초록키워드】 pandemic, diagnostic, Acute kidney injury, Symptom, adverse outcomes, Acute cardiac injury, global pandemic, Clinical course, healthcare, Algorithm, Patient, age, multivariate regression analysis, patients, acute respiratory distress, retrospective, Altered mental status, Admitted Patient, Older, 95% CI, increased risk, syndrome, help, single center, positive COVID-19, prognostic indicator, greater, was used, determine, reduce, presenting, with COVID-19, 【제목키워드】 Altered,