Antibody responses to pneumococcal polysaccharides are decreased in aged mice. Using a system to measure murine antibody responses to the Pnu-Imune vaccine, here we demonstrate that interleukin-10 (IL-10) has an adjuvant effect in enhancing the vaccine response in the aged. IL-10 increased the vaccine responses of B cells from aged mice in vitro only if either T cells or macrophages were also present. The need for T cells or macrophages could be substituted by cytokines such as IL-1 or IL-5, which are normally made by these accessory cells. Thus, IL-10 appeared to act on B cells directly but it worked in conjunction with other cytokines to induce an antigen specific response. In vivo studies showed that IL-10 administration enhanced antibody responses not only to thymic independent antigens but also to thymic-dependent antigens such as sheep erythrocytes. These data suggest that IL-10 may be useful in enhancing vaccine-specific responses in situations in which the host is immunocompromised.
Interleukin-10 Enhances Immune Responses to Pneumococcal Polysaccharides and Sheep Erythrocytes in Young and Aged Mice
인터루킨-10은 젊은 쥐와 노령 쥐에서 폐렴구균 다당체 및 양 적혈구에 대한 면역 반응을 강화한다.
[Category] 폐렴구균 감염증,
[Article Type] journal-article
[Source] pubmed
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