Abstract
Innate immune mechanisms are central players in response to the binding of pathogens to pattern-recognition receptors providing a crucial initial block on viral replication. Moreover, innate immune response mobilizes cells of the cellular-mediated immune system, which develop into effector cells that promote viral clearance. Here, we observed circulating leukocyte T cell response in healthy subjects, COVID-19 infected, and in healthy vaccinated subjects. We found a significant CD8 + T cells (p < 0,05) decrease and an augmented CD4 + /CD8 + ratio (p < 0,05) in COVID-19 infected group compared with vaccinated subjects. In addition, healthy vaccinated subjects have a significant increased expression of CD8 + T cells, and a reduction of CD4 + /CD8 + ratio with respect to subjects previously COVID-19 infected. Central Memory and Terminal Effector Memory cells (TEMRA) increased after vaccine but not among groups.
Keywords: COVID-19 infection; COVID-19 mRNA BNT162b2 (Pfizer-BioNTech) vaccine; Flow cytometry characterization; T cell immune response.
【저자키워드】 COVID-19 infection, COVID-19 mRNA BNT162b2 (Pfizer-BioNTech) vaccine, Flow cytometry characterization, T cell immune response, 【초록키워드】 COVID-19, Vaccine, immune response, innate immune response, T cells, immune system, CD4, CD8, viral clearance, T cell, pathogen, viral replication, receptor, Pfizer-BioNTech, T cell response, immune mechanism, binding, Innate, Cytometry, Flow, leukocyte, reduction, increased expression, subject, healthy subjects, circulating, terminal, effector, TEMRA, Cell, decrease, initial, develop, healthy, addition, subjects, promote, groups, COVID-19 mRNA BNT162b2, effector cell, 【제목키워드】 vaccination, Infection, Population, leucocyte, subject, circulating, healthy subject,