Abstract
Background: Malnutrition is seen in COVID-19 patients, and reducing malnutrition with appropriate therapies may improve these patients’ health. This case-control study aimed to assess and compare serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients with respiratory infections that receive glutamine treatment with a control group.
Methods: In this study, patients who consented to use glutamine were considered as the case group and other patients who did not use glutamine were considered as a control group. Two hundred twenty-two COVID-19 patients (51.2 ± 6.7) using L-Glutamine and 230 COVID-19 patients (51.3 ± 8.2) with similar age, gender, and clinical status, as the control group, were included in the study. For 5 days, the case group consumed 10 g of glutamine supplement three times per day. At the end of the 5 days, blood samples were taken again to test for serum levels of IL1β, tumor necrosis factor-α, malondialdehyde, and total antioxidant capacity, then all data were analyzed.
Results: Serum levels of β-1 interleukin, tumor necrosis factor-α and hs-CRP were significantly reduced with five days of glutamine supplementation (p < 0.05), and patients’ appetite during 5 days of glutamine supplementation compared with the control group had a significant increase (p < 0.05).
Conclusion: Glutamine supplementation in COVID-19 patients with respiratory infection significantly reduces serum levels of interleukin-1 β, hs-CRP, and tumor necrosis factor-α and significantly increases appetite, so glutamine supplementation may be useful for COVID-19 patients in the hospital.
Keywords: Appetite; COVID-19; Glutamine; Oxidative stress.
【저자키워드】 COVID-19, oxidative stress., Glutamine, Appetite, 【초록키워드】 Treatment, therapy, Stress, hospital, Gender, oxidative stress, inflammatory factors, clinical status, respiratory infection, Health, Patient, age, Malnutrition, COVID-19 patients, case-control study, COVID-19 patient, tumor necrosis factor-α, control group, Serum level, significant increase, blood sample, total antioxidant capacity, IL1β, FIVE, IMPROVE, analyzed, significantly, reduced, per day, increase, reducing, reduce, receive, L-Glutamine, 【제목키워드】 oxidative stress, inflammatory factors, case-control study, Serum level,