Abstract
Background: Older age and comorbidities are the main risk factors for adverse COVID-19 outcomes in patients with inflammatory bowel disease (IBD). The impact of IBD medications is still under investigation.
Aims: To assess risk factors for adverse outcomes of COVID-19 in IBD patients and use the identified risk factors to build risk indices.
Methods: Observational cohort study. Univariable and multivariable logistic regression was used to identify risk factors associated with pneumonia, hospitalisation, need for ventilatory support, and death.
Results: Of the 937 patients (446 with ulcerative colitis [UC]) evaluated, 128 (13.7%) had asymptomatic SARS-CoV-2 infection, 664 (70.8%) had a favourable course, and 135 (15.5%) had moderate or severe COVID-19. In UC patients, obesity, active disease and comorbidities were significantly associated with adverse outcomes. In patients with Crohn’s disease (CD), age, obesity, comorbidities and an additional immune-mediated inflammatory disease were identified as risk factors. These risk factors were incorporated into two indices to identify patients with UC or CD with a higher risk of adverse COVID-19 outcomes. In multivariable analyses, no single IBD medication was associated with poor COVID-19 outcomes, but anti-TNF agents were associated with a lower risk of pneumonia in UC, and lower risks of hospitalisation and severe COVID-19 in CD.
Conclusion: The course of COVID-19 in patients with IBD is similar to that in the general population. IBD patients with active disease and comorbidities are at greater risk of adverse COVID-19 outcomes. IBD medications do not pose additional risks. The risk indices may help to identify patients who should be prioritised for COVID-19 re-vaccination or for therapies for SARS-CoV-2 infection.
【초록키워드】 COVID-19, therapy, Risk factors, severe COVID-19, Pneumonia, SARS-COV-2 infection, obesity, Comorbidity, risk, outcome, risk factor, adverse outcomes, cohort study, adverse outcome, Inflammatory bowel disease, outcomes, Asymptomatic, Patient, death, age, General population, medication, hospitalisation, disease, moderate, patients, IBD, Immune-mediated, ulcerative colitis, Active disease, ventilatory support, higher risk, anti-TNF, multivariable logistic regression, help, lower risk, multivariable analyses, inflammatory disease, Course, greater, identify, was used, significantly, evaluated, build, COVID-19 in patient, 【제목키워드】 SARS-CoV-2, risk, adverse outcome, Inflammatory bowel disease,