Abstract
Background
Both obesity and type 2 diabetes (T2D) are reported to be highly enriched in hospitalized COVID-19 patients. Due to the close correlation between obesity and T2D, it is important to examine whether obesity and T2D are independently related to COVID-19 hospitalization.
Objective
To examine the causal effect of obesity and T2D in hospitalized COVID-19 patients using Mendelian randomization (MR).
Research design and methods
This two-sample MR analysis applied genetic markers of obesity identified in the genome wide association study (GWAS) by the GIANT Consortium as instrumental variables (IVs) of obesity; and genetic markers of T2D identified by the DIAGRAM Consortium as IVs of T2D. The MR analysis was performed in hospitalized COVID-19 patient by the COVID-19 Host Genetics Initiative using the MR-Base platform.
Results
All 3 classes of obesity (Class 1/2/3) were shown as the causal risk factors of COVID-19 hospitalization; however, T2D doesn’t increase the risk of hospitalization or critically ill COVID-19 as an independent factor.
Conclusions
Obesity, but not T2D, is a primary risk factor of COVID-19 hospitalization.
【저자키워드】 COVID-19, Hospitalization, mendelian randomization, obesity, type 2 diabetes, 【초록키워드】 Genome, risk, risk factor, Critically ill, Patient, COVID-19 hospitalization, GWAS, correlation, platform, association, hospitalized COVID-19 patient, Research design, Analysis, T2D, hospitalized COVID-19 patients, class, hospitalized COVID-19, initiative, objective, independent, instrumental variable, genetic marker, Result, shown, reported, applied, was performed, type 2 diabete, 【제목키워드】 hospitalized COVID-19 patient, type 2 diabete,