Abstract
Background
COVID-19 is associated with several risk factors such as distinct ethnicities (genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The authors aim to evaluate the correlation between variability in the host genetics and the severity and susceptibility towards COVID-19 in this study.
Methods
Following the PRISMA guidelines, we retrieved all the relevant articles published until September 15, 2021, from two online databases: PubMed and Scopus.
Findings
High-risk HLA haplotypes, higher expression of ACE polymorphisms, and several genes of cellular proteases such as TMPRSS2, FURIN, TLL-1 increase the risk of susceptibility and severity of COVID-19. In addition, upregulation of several genes encoding for both innate and acquired immune systems proteins, mainly CCR5, IFNs, TLR, DPPs, and TNF, positively correlate with COVID-19 severity. However, reduced expression or polymorphisms in genes affecting TLR and IFNλ increase COVID-19 severity.
Conclusion
Higher expression, polymorphisms, mutations, and deletions of several genes are linked with the susceptibility, severity, and clinical outcomes of COVID-19. Early treatment and vaccination of individuals with genetic predisposition could help minimize the severity and mortality associated with COVID-19.
【저자키워드】 SARS-CoV-2, host genetics, COVID-19 severity, Polymorphisms, genetic susceptibility, 【초록키워드】 COVID-19, Treatment, TMPRSS2, vaccination, Mortality, susceptibility, severity, Genetic, mutations, Comorbidities, polymorphism, risk, Proteins, immune system, smoking, risk factor, genetics, Clinical outcome, severity of COVID-19, Deletion, age, correlation, expression, CCR5, IFNs, TNF, ACE, Genetic predisposition, individual, Variability, help, upregulation, article, finding, HLA haplotypes, cellular protease, TLR, evaluate, addition, reduced, several gene, affecting, IFNλ, retrieved, with COVID-19, 【제목키워드】 susceptibility, systematic review, association, genetic risk,