Abstract
Mitochondria dynamics have a pivotal role in many aspects of immune function. Viral infections affect mitochondrial dynamics and trigger the release of mitochondrial DNA (mtDNA) in host cells. Released mtDNA guides the immune response towards an inflammatory response against pathogens. In addition, circulating cell-free mtDNA (ccf-mtDNA) is considered an invaluable indicator for the prognosis and severity of infectious diseases. This study provides an overview of the role of mtDNA in the dynamics of the immune response to COVID-19. We focused on the possible roles of mtDNA in inducing the signaling pathways, and the inflammasome activation and regulation in SARS-CoV-2. Targeting mtDNA-related pathways can provide critical insights into therapeutic strategies for COVID-19.
【저자키워드】 Coronavirus disease 2019, intensive care unit, angiotensin-converting enzyme 2, Toll-like receptor, Idiopathic pulmonary fibrosis, Endoplasmic reticulum, cystic fibrosis, mitochondrial DNA, transmembrane serine protease 2, Human immunodeficiency virus, mesenchymal stem cell, long non-coding RNA, Open reading frame, chronic obstructive pulmonary disease, severe acute respiratory coronavirus 2, COVID-19coronavirus disease 2019, ICUIntensive Care Unit, HIVhuman immunodeficiency virus, COPDchronic obstructive pulmonary disease, ACE2angiotensin-converting enzyme 2, MtDNAmitochondrial DNA, ccf-mtDNAcirculating cell-free mitochondrial DNA, circulating cell-free mitochondrial DNA, SARS-CoV-2severe acute respiratory coronavirus 2, DAMPdamage-associated molecular pattern, damage-associated molecular pattern, TLRToll-like receptor, Mt-DAMPmitochondrial- damage-associated molecular pattern, mitochondrial- damage-associated molecular pattern, MAVSmitochondrial antiviral signaling, mitochondrial antiviral signaling, HPVhuman papillomavirus, human papillomavirus, ISGinterferon stimulatory gene, interferon stimulatory gene, ROSreactive oxidative stress, reactive oxidative stress, TMPRSS2transmembrane serine protease 2, PRRpathogen-recognition receptors, pathogen-recognition receptors, MyD88myeloid differentiation factor 88, myeloid differentiation factor 88, cGASCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase, Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase, STINGstimulator of interferon genes, stimulator of interferon genes, ERendoplasmic reticulum, CFcystic fibrosis, IPFidiopathic pulmonary fibrosis, ORFopen reading frame, NBDnucleotide binding domain, nucleotide binding domain, LRRleucine rich repeat, leucine rich repeat, NLRnucleotide binding domain and leucine rich repeat, nucleotide binding domain and leucine rich repeat, mtROSmitochondrial reactive oxygen species, mitochondrial reactive oxygen species, lncRNAlong non-coding RNA, AIM2Absent in melanoma 2, Absent in melanoma 2, GSDMDgasdermin D, gasdermin D, MSCMesenchymal stem cell, 【초록키워드】 COVID-19, SARS-CoV-2, Mitochondria, immune response, Diseases, Prognosis, severity, Infection, DNA, pathway, immune function, Pathogens, signaling pathways, Critical, therapeutic strategy, Inflammatory response, mitochondrial, host cells, Regulation, inflammasome activation, circulating, targeting, Affect, addition, provide, 【제목키워드】 COVID-19, immune response, DNA, mitochondrial, role,