Abstract
HLA is a polymorphic antigen presenter which has provided valuable information on the susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific susceptibility or resistance alleles to severe COVID-19 in an ethnically dependent manner. This pilot study investigated HLA alleles associated with COVID-19 severity in Tapachula, Chiapas, Mexico. A total of 146 Mexican Mestizos were typed for HLA class I and II using PCR-SSP. The patients were classified according to the outcome (death or improvement) and the infection’s severity (mild or severe). In addition, a group of exposed uninfected individuals was included. HLA-A*68 was found to be a protective allele against the severe infection and fatal outcome; pC = 0.03, OR = 0.4, 95% CI =0.20–0.86, and pC =0.009, OR = 0.3, 95% CI =0.13–0.71 respectively. HLA-DRB1*03 also appears to be a protective factor against fatal outcome pC = 0.009, OR = 0.1, 95%IC = 0.01–0.66; however, the low frequency of this allele in the studied population limits the statistical power. The severity and fatal outcome of COVID-19 patients in Tapachula, Chiapas depend more on the lack of resistance than susceptibility HLA alleles.
【저자키워드】 COVID-19, SARS-CoV-2, Mexico, HLA, MHC, 【초록키워드】 viruses, Severe infection, severe COVID-19, susceptibility, severity, Infection, outcome, Population, Antigen, Patient, death, Mild, Statistical power, information, Protective, Frequency, HLA class I, COVID-19 patient, 95% CI, pilot study, individual, HLA alleles, protective factor, allele, HLA allele, uninfected, limit, lack, addition, investigated, provided, appear, Mestizo, PCR-SSP, with COVID-19, 【제목키워드】 allele, HLA allele,