Abstract
Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the major driver of pathology in severe COVID-19. In this pandemic, considerable effort is being focused on identifying host genomic factors that increase susceptibility or resistance to the complications of COVID-19 and translating these findings to improved patient care. In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. Valuable genomic insights into the chemokine receptor-ligand nexus have been gained from HIV infection and disease progression studies. Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients.
【저자키워드】 COVID-19, HIV/AIDS, host genetics, CCR5, 【초록키워드】 Treatment, pathology, Treatment outcome, pandemic, Pathogenesis, severe COVID-19, knowledge, susceptibility, chemokine, Cytokine release syndrome, Disease progression, Host immune response, genomic, severe COVID-19 disease, COVID-19 patients, HIV infection, Patient care, Factor, effort, life-threatening, complications of COVID-19, Host, reported, “cytokine storm”, Applying, with COVID-19, 【제목키워드】 knowledge, polymorphism, receptor,