Abstract
Background and aims
Observational studies showed that coronavirus disease (2019) (COVID-19) attacks universally and its most menacing progression uniquely endangers the elderly with cardiovascular disease (CVD). The causal association between COVID-19 infection or its severity and susceptibility of atrial fibrillation (AF) remains unknown.
Methods and results
The bidirectional causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with not hospitalized COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and AF are determined by using two-sample Mendelian randomization (MR) analysis. Genetically predicted severe COVID-19 was not significantly associated with the risk of AF [odds ratio (OR), 1.037; 95% confidence interval (CI), 1.005–1.071; P = 0.023, q = 0.115]. In addition, genetically predicted AF was also not causally associated with severe COVID-19 (OR, 0.993; 95% CI, 0.888–1.111; P = 0.905, q = 0.905). There was no evidence to support the association between genetically determined COVID-19 and the risk of AF (OR, 1.111; 95% CI, 0.971–1.272; P = 0.127, q = 0.318), and vice versa (OR, 1.016; 95% CI, 0.976–1.058; P = 0.430, q = 0.851). Besides, no significant association was observed for hospitalized COVID-19 with AF. MR-Egger analysis indicated no evidence of directional pleiotropy.
Conclusion
Overall, this MR study provides no clear evidence that COVID-19 is causally associated with the risk of AF.
【저자키워드】 Coronavirus disease 2019, Atrial fibrillation, Bidirectional Mendelian randomization, 【초록키워드】 COVID-19, coronavirus disease, severe COVID-19, susceptibility, mendelian randomization, severity, risk, cardiovascular disease, progression, observational study, COVID-19 infection, bidirectional, General population, association, Evidence, Analysis, Support, CVD, 95% CI, 95% confidence interval, hospitalized COVID-19, attack, MR-Egger, MR study, predicted, significantly, indicated, addition, provide, directional pleiotropy, 【제목키워드】 COVID-19, mendelian randomization, bidirectional, association, Causal,