Abstract Background The aim was to assess factors affecting disease severity in imported P. falciparum and non- falciparum malaria. Methods We reviewed medical records from 2793/3260 (85.7%) of all episodes notified in Sweden between 1995 and 2015 and performed multivariable logistic regression. Results Severe malaria according to WHO 2015 criteria was found in P. falciparum (9.4%), P. vivax (7.7%), P. ovale (5.3%), P. malariae (3.3%), and mixed P. falciparum episodes (21.1%). Factors associated with severe P. falciparum malaria were age <5 years and >40 years, origin in nonendemic country, pregnancy, HIV, region of diagnosis, and health care delay. Moreover, oral treatment of P. falciparum episodes with parasitemia ≥2% without severe signs at presentation was associated with progress to severe malaria with selected criteria. In non- falciparum , age >60 years, health care delay and endemic origin were identified as risk factors for severe disease. Among patients originating in endemic countries, a higher risk for severe malaria, both P. falciparum and non- falciparum , was observed among newly arrived migrants. Conclusions Severe malaria was observed in P. falciparum and non- falciparum episodes. Current WHO criteria for severe malaria may need optimization to better guide the management of malaria of different species in travelers and migrants in nonendemic areas. We investigated risk factors for severe malaria in approximately 2700 cases of imported malaria. We identified variables associated with severity of P. falciparum and non- falciparum infections that need to be considered in the management of malaria in travelers and migrants.
【저자키워드】 migrants, Plasmodium, severe malaria, Falciparum, Imported malaria, non-falciparum,