Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19

Published on
Journal: Synthetic and Systems Biotechnology
[저자] Jing Liu, Sheng Liu, Zhao Zhang, Xuejun Lee, Wenxuan Wu, Zhanlian Huang, Ziying Lei, Wenxiong Xu, Dabiao Chen, Xing Wu, Yang Guo, Liang Peng, Bingliang Lin, Yutian Chong, Xiangyu Mou, Mang Shi, Ping Lan, Tao Chen, Zhiliang Gao
[Category] 바이오마커, 유전자 메커니즘,
[DOI] 10.1016/j.synbio.2021.06.002    
[Article Type] Research article
[Source] Sciencedirect

Abstract
SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, the interaction between SARS-CoV-2 and nasopharyngeal microbiota, and the association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients, and metagenomic analysis of pharyngeal samples were used to identify the key features of COVID-19. Results showed lactic acid, l-proline, and chlorogenic acid methyl ester (CME) were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 ones. Nasopharyngeal commensal bacteria including Gemella morbillorum, Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients, while Prevotella histicola, Streptococcus sanguinis, and Veillonella dispar were relatively increased. The abundance of G. haemolysans and L. hofstadii were significantly positively associated with serum CME, which might be an anti-SARS-CoV-2 bacterial metabolite. This study provides important information to explore the linkage between nasopharyngeal microbiota and disease susceptibility. The findings were based on a very limited number of patients enrolled in this study; a larger size of cohort will be appreciated for further investigation.

All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, susceptibility, metabolome, Nasopharyngeal microbiome, 【초록키워드】 Local, anti-SARS-CoV-2, Nasopharyngeal swab, serum, Cohort, microbiota, nasopharyngeal, sera, Patient, Urine, respiratory tract, information, disease, COVID-19 patients, Blood, association, Interaction, Analysis, Prevotella, COVID-19 patient, Non-COVID-19, Non-COVID-19 patients, lactic acid, commensal bacteria, pharyngeal, Streptococcus, infect, feature, metabolomic analysis, bacterial metabolite, Leptotrichia, Result, enrolled, identify, significantly, reduced, characterized, provide, were used, metagenomic, 【제목키워드】 nasopharyngeal, Microbiome, patients with COVID-19,