Abstract
Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.
【저자키워드】 Coronavirus disease 2019, bone marrow failure, COVID-19coronavirus disease 2019, DCDyskeratosis Congenita, Dyskeratosis Congenita, BMFBone Marrow Failure, TLTelomere Length, Telomere Length, 【초록키워드】 COVID-19, stem cells, RNA, symptomatic, Patient, mortality rate, clinical care, disease, association, leukocyte, higher risk, complex, heterogeneous, disorder, transcriptase, telomerase, indicated, increase, mutated, severe symptom, 【제목키워드】 symptomatic, Patient, higher risk,