ABSTRACT Coronavirus disease 2019 (COVID-19) is a highly infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory findings from a significant number of patients with COVID-19 indicate the occurrence of leukocytopenia, specifically lymphocytopenia. Moreover, infected patients can experience contrasting outcomes depending on lymphocytopenia status. Patients with resolved lymphocytopenia are more likely to recover, whereas critically ill patients with signs of unresolved lymphocytopenia develop severe complications, sometimes culminating in death. Why immunodepression manifests in patients with COVID-19 remains unclear. Therefore, the evaluation of clinical symptoms and laboratory findings from infected patients is critical for understanding the disease course and its consequences. In this review, we take a logical approach to unravel the reasons for immunodepression in patients with COVID-19. Following the footprints of the virus within host tissues, from entry to exit, we extrapolate the mechanisms underlying the phenomenon of immunodepression.
【저자키워드】 COVID-19, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, Cytokine storm, coronavirus, Immunosuppression, leukocytopenia, lymphocytopenia, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, Clinical symptoms, outcome, severe acute respiratory syndrome Coronavirus, virus, Laboratory, laboratory findings, Consequences, Critically ill, leukocytopenia, lymphocytopenia, death, viral disease, respiratory, Critical, mechanism, critically ill patients, Critically ill patient, acute respiratory syndrome, acute respiratory syndrome coronavirus, infected patients, acute respiratory syndrome coronavirus 2, tissues, exit, clinical symptom, phenomenon, disease course, severe complications, Host, approach, Occurrence, Course, develop, caused, the disease, infected patient, resolved, patients with COVID-19, 【제목키워드】 immune responses, consequence,