Abstract A decreased lung diffusing capacity for carbon monoxide (DL CO ) has been reported in a variable proportion of subjects over the first 3 months of recovery from severe coronavirus disease 2019 (COVID‐19). In this study, we investigated whether measurement of lung diffusing capacity for nitric oxide (DL NO ) offers additional insights on the presence and mechanisms of gas transport abnormalities. In 94 subjects, recovering from mild‐to‐severe COVID‐19 pneumonia, we measured DL NO and DL CO between 10 and 266 days after each patient was tested negative for severe acute respiratory syndrome coronavirus 2. In 38 subjects, a chest computed tomography (CT) was available for semiquantitative analysis at six axial levels and automatic quantitative analysis of entire lungs. DL NO was abnormal in 57% of subjects, independent of time of lung function testing and severity of COVID‐19, whereas standard DL CO was reduced in only 20% and mostly within the first 3 months. These differences were not associated with changes of simultaneous DL NO /DL CO ratio, while DL CO /V A and DL NO /V A were within normal range or slightly decreased. DL CO but not DL NO positively correlated with recovery time and DL CO was within the normal range in about 90% of cases after 3 months, while DL NO was reduced in more than half of subjects. Both DL NO and DL CO inversely correlated with persisting CT ground glass opacities and mean lung attenuation, but these were more frequently associated with DL NO than DL CO decrease. These data show that an impairment of DL NO exceeding standard DL CO may be present during the recovery from COVID‐19, possibly due to loss of alveolar units with alveolar membrane damage, but relatively preserved capillary volume. Alterations of gas transport may be present even in subjects who had mild COVID‐19 pneumonia and no or minimal persisting CT abnormalities. Trial registry ClinicalTrials.gov PRS: No.: NCT04610554 Unique Protocol ID: SARS‐CoV‐2_DLNO 2020. An impairment of lung diffusing capacity for nitric oxide exceeding standard DL CO may be present during the recovery from COVID‐19, possibly due to loss of alveolar units with alveolar membrane damage
【저자키워드】 COVID‐19, nitric oxide, alveolar membrane diffusive conductance, carbon monoxide, ground glass opacities, lung diffusing capacity, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, Pneumonia, nitric oxide, severity, lung, severe acute respiratory syndrome Coronavirus, COVID‐19, Computed tomography, Chest computed tomography, Lungs, carbon monoxide, Lung function, Patient, Mild, membrane, change, mechanism, Recovery time, Analysis, independent of, diffusing capacity, normal range, Volume, Ground glass opacity, Quantitative analysis, acute respiratory syndrome, gas transport, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, severe coronavirus disease, subject, These data, alteration, Abnormalities, impairment, abnormal, semiquantitative analysis, offer, alveolar, decrease, independent, proportion, reported, investigated, subjects, correlated, was reduced, diffusing, positively correlated, preserved, was tested, 【제목키워드】 nitric oxide, COVID‐19, carbon monoxide, diffusing,