Summary
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, myocarditis, cardiomyocyte, engineered heart tissue, 【초록키워드】 COVID-19, pathology, viral infection, coronavirus, thrombosis, viral pathogenesis, Infection, emerging disease, systemic inflammation, cell death, mechanism, cytokine production, Evidence, acute respiratory syndrome, cardiac complication, pathogenesis of COVID-19, direct infection, heart tissue, susceptible, Myocardial, provide, contractile, patients with COVID-19, 【제목키워드】 COVID-19, SARS-CoV-2, Human, Model,