Common antigens were shown in T. rubrum, T. mentagrophytes, Hormodendrum sp., and Penicillium sp. by agar gel diffusion, hemagglutination, and hemagglutination-inhibition tests. The immune response of rabbits to injections of dermatophyte mycelium was shown by the development of a state of hypersensitivity and by antibody production. Antibody in rabbit anti-dermatophyte serum could be completely removed by absorption with dermatophyte mycelium but only partially by mycelium of Penicillium sp., indicating that the sera of animals immunized with dermatophytes contain antibody specific for the dermatophytes as well as antibody directed against a common antigen found in dermatophytes, Hormodendrum sp., and Penicillium sp. Antibody against T. rubrum was found in the sera of 93 adult Negroes and Caucasians tested, irrespective of the presence or absence of clinical ringworm, and in 27 out of 35 Caucasian children without ringworm. Titers among children were lower than among adults. Titers among apparently normal adults did not differ significantly from those with ringworm. Antibody in human serum could be completely removed by absorption with mycelia of Hormodendrum sp., Penicillium sp., or dermatophyte, suggesting formation as a result of previous contact with either dermatophyte or saprophyte.
Concerning the Specificity of Dermatophyte-Reacting Antibody in Human and Experimental Animal Sera**From the Department of Microbiology, School of Medicine, Tulane University, New Orleans, Louisiana.
인간 및 실험 동물 혈청에서 피부사상균 반응 항체의 특이성에 관한 연구**루이지애나주 뉴올리언스 튤레인 대학교 의과대학 미생물학과에서.
[Category] 백선증,
[Article Type] journal-article
[Source] pubmed
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