The WHO defines different COVID-19 disease stages in which the pathophysiological mechanisms differ. We evaluated the characteristics of these COVID-19 disease stages. Forty-four PCR-confirmed COVID-19 patients were included in a prospective minimal invasive autopsy cohort. Patients were classified into mild-moderate (n = 4), severe-critical (n = 32) and post-acute disease (n = 8) and clinical, radiological, histological, microbiological and immunological data were compared. Classified according to Thoracic Society of America, patients with mild-moderate disease had no typical COVID-19 images on CT-Thorax versus 71.9% with typical images in severe-critical disease and 87.5% in post-acute disease ( P < 0.001). Diffuse alveolar damage was absent in mild-moderate disease but present in 93.8% and 87.5% of patients with severe-critical and post-acute COVID-19 respectively ( P = 0.002). Other organs with COVID-19 related histopathological changes were liver and heart. Interferon-γ levels were significantly higher in patients with severe-critical COVID-19 ( P = 0.046). Anti-SARS CoV-2 IgG was positive in 66%, 40.6% and 87.5% of patients with mild-moderate, severe-critical and post-acute COVID-19 respectively (n.s.). Significant differences in histopathological and immunological characteristics between patients with mild-moderate disease compared to patients with severe-critical disease were found, whereas differences between patients with severe-critical disease and post-acute disease were limited. This emphasizes the need for tailored treatment of COVID-19 patients.
【저자키워드】 Inflammation, viral infection, Pathogenesis, Infection, clinical microbiology, Immunopathogenesis, 【초록키워드】 COVID-19, Treatment, IgG, interferon, Autopsy, COVID-19 disease, Cohort, Characteristics, heart, Patient, WHO, Diffuse alveolar damage, Other, disease, change, liver, COVID-19 patients, alveolar damage, Society, interferon-γ, significant differences, stages, other organs, Stage, pathophysiological mechanism, America, diffuse, positive, organ, pathophysiological mechanisms, immunological characteristics, immunological, invasive, radiological, evaluated, significantly higher, had no, histopathological, Significant, histological, PCR-confirmed COVID-19 patient, with COVID-19, 【제목키워드】 Evolution, Autopsy, Stage, immunological, invasive, radiological, histological,