Eight patients with non-Hodgkin’s lymphoma who have been in complete clinical remission for the mean of 23.3 months were evaluated for their antibody responses to a pneumococcal vaccine. The results were correlated with lymphocyte subpopulations, serum immunoglobulin levels, and in vitro mitogenic responses to phytohemagglutinin, concanavalin and pokeweed mitogen. Two patients with normal antibody responses had immunoglobulin levels and mitogenesis within the range of controls. Impaired antibody responses in the remaining six patients were correlated either with marked depressed mitogenesis to phytohemagglutinin or with low levels of IgA. Impaired humoral immune responses seem to persist in these patients even after several months of sustained clinical remission.
Impaired antibody responses to a pneumococcal polysaccharide vaccine in patients with non-Hodgkin’s lymphoma in remission
비호지킨 림프종이 완화된 환자에서 폐렴구균 다당류 백신에 대한 항체 반응 저하
[Category] 폐렴구균 감염증,
[Article Type] journal-article
[Source] pubmed
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