Abstract
We report multiple single nucleotide polymorphism taken at different time interval during treatment of COVID-19. Gene sequencing showed mutation within ORF1b at position P314L. Mutation at this point has been shown to impose structural remodelling that increases the affinity for remdesivir binding and may also affect binding affinity for favipiravir.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, next generation sequencing, Genetic variations, 【초록키워드】 Treatment, Mutation, Sequencing, polymorphism, Remdesivir, Favipiravir, binding affinity, single nucleotide, binding, ORF1b, Affect, shown, increase, 【제목키워드】 Treatment, Variation, Sequencing, individual, whole genome, FIVE,
【저자키워드】 COVID-19, SARS-CoV-2, next generation sequencing, Genetic variations, 【초록키워드】 Treatment, Mutation, Sequencing, polymorphism, Remdesivir, Favipiravir, binding affinity, single nucleotide, binding, ORF1b, Affect, shown, increase, 【제목키워드】 Treatment, Variation, Sequencing, individual, whole genome, FIVE,