Abstract
The COVID-19 pandemic has led to severe financial, clinical, and societal repercussions and imposed more pressure on the healthcare system of many nations. COVID-19 impacts the immune system by causing a systemic inflammatory reaction, often known as cytokine release syndrome (CRS). COVID-19 patients had elevated levels of pro-inflammatory cytokines and chemokines. In this context, many dietary interventions have been utilized to mitigate the adverse effects of COVID-19 by regulating the excessive secretion of cytokines and chemokines. Zinc, an anti-inflammatory and antioxidant mineral in food with a well-established role in immunity, is now being employed in several clinical studies against COVID-19. Zn deficiency has been correlated with the increased production of pro-inflammatory cytokines. As a result, we will summarise zinc’s immunomodulatory effects in this article. We will investigate how zinc deficiency might contribute to a poor prognosis of COVID-19 disease by altering the release of particular cytokines.
【저자키워드】 COVID-19, SARS-CoV-2, Zinc, Cytokines, immunomodulation, 【초록키워드】 Immunity, Anti-inflammatory, COVID-19 pandemic, Intervention, cytokine, chemokines, immune system, antioxidant, Cytokine release syndrome, COVID-19 disease, Impact, pro-inflammatory cytokines, CRS, clinical study, COVID-19 patient, Healthcare system, deficiency, adverse effect, poor prognosis, pro-inflammatory cytokine, excessive secretion, immunomodulatory effect, mitigate, systemic inflammatory, elevated, contribute, correlated, 【제목키워드】 COVID-19 severity, Effect,