At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.
【저자키워드】 immunology, viral infection, Infectious diseases, Microbiology, 【초록키워드】 SARS-CoV-2, IgG, coronavirus, Infection, severe acute respiratory syndrome Coronavirus, Infant, pregnant women, Infants, Newborn, Seroconversion, Characteristics, Birth, serum antibody, respiratory, positive rate, SARS-CoV-2 IgG, mother, life, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, transfer, present, parturient, described, analyzed, provide, less, dropped, infected with SARS-CoV-2, 【제목키워드】 Infant, change, dynamic,