Abstract
People living with HIV are more exposed to the adverse health effects of the worldwide COVID-19 pandemic. The pandemic’s health and social repercussions may promote drug abuse and inadequate HIV management among this demographic. The coronavirus pandemic of 2019 (COVID-19) has caused unprecedented disruption worldwide in people’s lives and health care. When the COVID-19 epidemic was identified, people with HIV faced significant obstacles and hurdles to achieving optimal care results. The viral spike protein (S-Protein) and the cognate host cell receptor angiotensin-converting enzyme 2 (ACE2) are both realistic and appropriate intervention targets. Calanolides A, Holy Basil, Kuwanon-L, and Patentiflorin have anti-HIV effects. Our computational biology study investigated that these compounds all had interaction binding scores related to S protein of coronavirus of −9.0 kcal /mol, −7.1 kcal /mol, −9.1 kcal /mol, and −10.3 kcal/mol/mol, respectively. A combination of plant-derived anti-HIV compounds like protease inhibitors and nucleoside analogs, which are commonly used to treat HIV infection, might be explored in clinical trials for the treatment of COVID-19.
【저자키워드】 COVID-19, HIV, ACE2, S protein, Calanolides A, Holy Basil, Kuwanon-L, Patentiflorin A, 【초록키워드】 Treatment, coronavirus, clinical trial, pandemic, COVID-19 pandemic, Intervention, angiotensin-converting enzyme 2, Protease inhibitor, Health, management, targets, Care, nucleoside analogs, HIV infection, Combination, Interaction, COVID-19 epidemic, viral spike protein, Compound, host cell receptor, treat, Effect, Effects, BASIL, caused, investigated, these compound, promote, with HIV, binding score, people with HIV, 【제목키워드】 Compound, Can,