Abstract
Objective
To describe the clinical characteristics and outcomes of CVT in patients with history of recent COVID-19 infection or vaccination.
Methods
We reviewed demographic, clinical, and radiographic characteristics of non-pyrogenic, non-traumatic CVT cases at our multi-center institution between March 2020 and December 2021. Patients were grouped according to their history of recent COVID-19 infection or vaccination into group-I (+COVID-19 association) and group-II (-COVID-19 association).
Results
Fifty-one patients with CVT were included, of which 14 (27.4%) had a positive COVID-19 association: 10 with infection and 4 with mRNA-COVID-vaccine. Nine patients in group-I had COVID-19 infection or vaccine within 30 days of CVT diagnosis, including 3 patients with active infection at the time of CVT diagnosis. Half of the patients in group-I (n = 7,50.0%) and 32.4% (n = 12) of group-II were male, and mean age was 52.6 years in group-I and 51.4 years in group-II. Fever at presentation was noted in one patient who had active COVID infection (I=1 (7.1%), II= 0 (0%)). Higher rates of comorbidities were observed in group-II: hypertension (I= 2 (14.3%), II= 13 (35.1%)), deep venous thrombosis(I=1(7.1%), II= 10 (27.0%)), pulmonary emboli (I=1(7.1%), II= 8(21.6%)), or stroke(I=0(0%), II= 6(16.4%)). Three patients had thrombocytopenia at the time of CVT diagnosis (5.4%) and most patients (n = 37, 72.5%) were treated medically with anticoagulation. Complication rate during hospitalization was 17.6% (n = 6), and no mortality was noted.
Conclusion
Twenty-seven percent of CVT patients were associated with COVID-19 infection or vaccination, and the majority presented within 30 days of infection/vaccination.
【저자키워드】 coronavirus, stroke, COVID, hemorrhage, cerebral vein thrombosis, 【초록키워드】 Vaccine, vaccination, Mortality, anticoagulation, Hospitalization, Clinical characteristics, Infection, Diagnosis, Comorbidity, outcome, hypertension, Characteristics, COVID-19 infection, male, Patient, Complication, age, association, Pulmonary emboli, Radiographic, positive COVID-19, objective, venous, Result, the patient, treated, majority, with COVID-19, 【제목키워드】 COVID-19, Venous thrombosis, cerebral,