Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C > T , CYP3A4*1B ( g.-392A>G), CYP3A5*3 ( g.6986A > G ) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
All Keywords
【저자키워드】 Angola, MDR1, CYP450, human polymorphism, Artemether–lumefantrine,
【저자키워드】 Angola, MDR1, CYP450, human polymorphism, Artemether–lumefantrine,