Abstract
With the outbreak and rapid spread of COVID-19, the world health situation is unprecedentedly severe. Systemic lupus erythematosus (SLE) is a common autoimmune disease, which can cause multiple organ damage. Numerous studies have shown that immune factors have important roles in the pathogenesis of both COVID-19 and SLE. In the early stages of COVID-19 and SLE pathogenesis, IFN-α expression is frequently increased, which aggravates the virus infection and promotes SLE development. In addition, increased IL-6 levels, caused by different mechanisms, are observed in the peripheral blood of patients with severe COVID-19 and SLE, stimulating a series of immune cascades that lead to a cytokine storm, as well as causing B cell hyperfunction and production of numerous of antibodies, aggravating both COVID-19 and SLE. In this review, we explore the background immunopathological mechanisms in COVID-19 and SLE and analyze the advantages and disadvantages of commonly used SLE drugs for patients with COVID-19, to optimize treatment plans for patients with SLE who develop COVID-19.
【저자키워드】 COVID-19, Treatment, IL-6, IFN-α, SLE, 【초록키워드】 antibodies, Cytokine storm, Pathogenesis, severe COVID-19, drug, Peripheral blood, B cell, Autoimmune disease, Health, outbreak, Patient, mechanisms, virus infection, expression, early stage, mechanism, Multiple organ damage, disadvantage, systemic, IL-6 levels, immune cascade, spread of COVID-19, shown, develop, caused, addition, promote, aggravate, immunopathological, Numerous, immune factor, patients with COVID-19, 【제목키워드】 drug, treat, event,