Abstract
Background
Patients having undergone B-cell-depletion with anti-CD20-antibodies have a higher risk of mortality, delayed viral clearance and prolonged infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report two cases of patients with persistent coronavirus disease 2019 (COVID-19) in association with B-cell-depletion that were treated with the monoclonal antibody Sotrovimab.
Case presentation
Both patients presented with chronic symptoms of COVID-19 such as dyspnea, fatigue, and chest pain. Nasopharyngeal swabs remained positive months after the initial infection with fluctuating cycle threshold (Ct) values around 30. Both patients received a single infusion with the monoclonal SARS-CoV-2 antibody Sotrovimab, which resulted in a rapid improvement of symptoms and inflammation markers as well as negative SARS-CoV-2 swabs. A follow-up after a month showed ongoing improvement of symptoms, persistent negative SARS-CoV-2 swabs, and positive serum antibodies.
Conclusion
Infusion with the monoclonal SARS-CoV-2 antibody led to rapid improvement in two patients with persistent COVID-19 after B-cell depletion.
【저자키워드】 Coronavirus disease 2019, monoclonal antibodies, polymerase chain reaction, cycle threshold, COVID-19coronavirus disease 2019, PCRpolymerase chain reaction, Ctcycle threshold, SARS-CoV-2Severe acute respiratory syndrome coronavirus type2, Severe acute respiratory syndrome coronavirus type2, mABsmonoclonal antibodies, LTOTLong term oxygen therapy, Long term oxygen therapy, CoV-2-S-ABSARS-CoV-2 S protein antibodies, SARS-CoV-2 S protein antibodies, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Mortality, fatigue, monoclonal antibody, Infection, Symptom, Symptoms, viral clearance, SARS-CoV-2 antibody, Dyspnea, swabs, Patient, Follow-up, Swab, Sotrovimab, monoclonal, B-cell, Prolonged infection, association, infusion, chest pain, acute respiratory syndrome, higher risk, symptoms of COVID-19, positive, initial, remained, treated, inflammation marker, positive serum antibodies, 【제목키워드】 COVID-19, monoclonal antibody, Sotrovimab, B-cell-depleted patient,