Summary
Objectives
We aimed to assess the short-term effectiveness of COVID-19 vaccines among immunocompromised patients to prevent laboratory-confirmed symptomatic COVID-19 infection.
Methods
Systematic review and meta-analysis. We calculated the pooled diagnostic odds ratio [DOR] (95% CI) for COVID-19 infection between immunocompromised patients and healthy people or those with stable chronic medical conditions. VE was estimated as 100% x (1-DOR). We also investigated the rates of developing anti-SARS-CoV-2 spike protein IgG between the 2 groups.
Results
Twenty studies evaluating COVID-19 vaccine response, and four studies evaluating VE were included in the meta-analysis. The pooled DOR for symptomatic COVID-19 infection in immunocompromised patients was 0.296 (95% CI: 0.108–0.811) with an estimated VE of 70.4% (95% CI: 18.9%- 89.2%). When stratified by diagnosis, IgG antibody levels were much higher in the control group compared to immunocompromised patients with solid organ transplant (pOR 232.3; 95% Cl: 66.98–806.03), malignant diseases (pOR 42.0, 95% Cl: 11.68–151.03), and inflammatory rheumatic diseases (pOR 19.06; 95% Cl: 5.00–72.62).
Conclusions
We found COVID-19 mRNA vaccines were effective against symptomatic COVID-19 among the immunocompromised patients but had lower VE compared to the controls. Further research is needed to understand the discordance between antibody production and protection against symptomatic COVID-19 infection.
【저자키워드】 Meta-analysis, COVID-19 vaccine, Immunocompromised patients, Effectiveness, 【초록키워드】 COVID-19, IgG, diagnostic, Diagnosis, anti-SARS-CoV-2, Spike protein, Immunocompromised patient, IgG antibody, COVID-19 infection, symptomatic, Research, solid organ transplant, Inflammatory, Odds ratio, Medical conditions, COVID-19 mRNA vaccine, antibody production, rheumatic disease, control group, 95% CI, malignant disease, laboratory-confirmed, objective, Prevent, controls, effective, Result, healthy, investigated, calculated, groups, much higher, stratified, 【제목키워드】 Immunocompromised, literature review,