Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs the respiratory system and multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes and inflammasome-mediated inflammatory signaling pathways, which are key determinants of hyperinflammation and cytokine storm in COVID-19 patients. Additionally, SARS-CoV-2 inhibits inflammasome activation to evade the host’s antiviral immunity. Therefore, regulating inflammasome initiation has received increasing attention as a preventive measure in COVID-19 patients. Ginseng and its major active constituents, ginsenosides and saponins, improve the immune system and exert anti-inflammatory effects by targeting inflammasome stimulation. Therefore, this review discussed the potential preventive and therapeutic roles of ginseng in COVID-19 based on its regulatory role in inflammasome initiation and the host’s antiviral immunity.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammasome, ginseng, Ginsenoside, Saponin, 【초록키워드】 coronavirus disease, Cytokine storm, coronavirus, Symptom, immune system, Regulatory, hyperinflammation, therapeutic, death, hyper-inflammation, Respiratory system, antiviral immunity, COVID-19 patients, Pathways, determinant, acute respiratory syndrome, multiple organs, inflammasome activation, anti-inflammatory effect, pathogenic virus, Host, inflammatory signaling, IMPROVE, inhibit, cause, evade, activate, impair, 【제목키워드】 benefit, Potential,