Abstract
Compared with the general population, patients receiving maintenance dialysis are at increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19). Currently, data on severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)-specific immunity post-vaccination in patients on maintenance dialysis are scarce given that the effectiveness of the vaccines has not been explicitly tested in this population due to their common exclusion from SARS-CoV-2 vaccination trials. We herein present data of the specific cellular (interferon-γ and interleukin-2 ELISpot assays) and humoral immune responses (dot plot array and chemiluminescent microparticle immunoassay) at 4 weeks and 6 weeks following a single dose or a complete homologous dual dose SARS-CoV-2 vaccine regimen in 60 adult patients on maintenance dialysis (six with a history of COVID-19). The data was produced in a framework of a project focused on a) quantifying the immune response after full vaccination, b) evaluating the short-term durability of immune response, and c) examining the reactogenicity of SARS-CoV-2 vaccine regimens in patients on maintenance dialysis.
【저자키워드】 SARS-CoV-2, Cellular immune response, T cells, immunoglobulins, Hemodialysis, Peritoneal dialysis, 【초록키워드】 COVID-19, coronavirus disease, coronavirus, immune response, vaccination, reactogenicity, Immunity, SARS-CoV-2 vaccine, dialysis, immunoassay, Patient, Effectiveness, morbidity and mortality, ELISPOT, humoral immune response, General population, homologous, trials, SARS-CoV-2 vaccination, single dose, cellular, dose, regimen, interferon-γ, acute respiratory syndrome, increased risk, exclusion, Microparticle, Complete, produced, tested, assays, receiving, the vaccine, 【제목키워드】 reactogenicity, dialysis, COVID-19 vaccination, Patient, receiving,