Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients—with 217 and 207 included in the first and second follow-up visits—were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Non-hospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized.
【저자키워드】 viral infection, Risk factors, Scientific data, Outcomes research, Statistics, Respiratory signs and symptoms, 【초록키워드】 COVID-19, Medical research, Hospitalized, fatigue, mental health, lung involvement, hospital, lung, Gender, Symptom, elderly patients, cohort study, Laboratory, Computed tomography, X-ray, ground-glass opacity, Pulmonary function, Characteristics, Chest CT, Patient, Spain, Follow-up, predictor, university, COVID-19 patients, association, High-resolution, bronchiectasis, lung lesions, thromboembolic, syndrome, manuscript, impairment, diagnosing, Effect, Thromboembolic event, robust, conducted, functional, correlated, induce, assigned, discharged, statistically, Bilateral, imaging abnormality, patients with COVID-19, subpleural, variables, 【제목키워드】 COVID-19, prospective cohort study, association,