Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
All Keywords
【저자키워드】 Uganda, parasites, malaria, Single nucleotide polymorphism, resistance, Child, Plasmodium falciparum, artesunate, kelch 13 propeller domain,
【저자키워드】 Uganda, parasites, malaria, Single nucleotide polymorphism, resistance, Child, Plasmodium falciparum, artesunate, kelch 13 propeller domain,