Abstract
Due to COVID 19 outbreak many studies are being conducted for therapeutic strategies and vaccines but detection methods play an important role in the containment of the disease. Hence, this systematic review aims to evaluate the effectiveness of the molecular detection techniques in COVID-19. For framing the systematic review 6 literature databases (PubMed, EMBASE, OVID, Web of Science, Scopus and Google Scholar) were searched for relevant studies and articles were screened for relevant content till 25th April 2020. Observations from this systematic review reveal the utility of RT-PCR with serological testing as one such method cannot correlate with accurate results. Availability of point of care devices do not conform to sensitivity and specificity in comparison to the conventional methods due to lack of clinical investigations. Pivotal aim of molecular and serological research is the development of detection methods that can support the clinical decision making of patients suspected with SARS-CoV-2. However, none of the methods were 100% sensitive and specific; hence additional studies are required to overcome the challenges addressed here. We hope that the present article with its observations and suggestions will assist the researchers to realize this vision in future.
【저자키워드】 angiotensin converting enzyme 2, Loop-mediated isothermal amplification, limit of detection, localized surface plasmon resonance, ACE2angiotensin converting enzyme 2, LSPRLocalized surface plasmon resonance, LoDlimit of detection, ICTVInternational committee on taxonomy of viruses, International committee on taxonomy of viruses, LAMPloop-mediated isothermal amplification, VIVALDIveterinary validation of point-of-care diagnostic instrument, veterinary validation of point-of-care diagnostic instrument, FETfield effect transistor, field effect transistor, 【초록키워드】 COVID-19, SARS-CoV-2, Vaccine, point of care, systematic review, RT-PCR, database, COVID 19, Serological testing, Sensitivity and specificity, outbreak, Research, Patient, Effectiveness, molecular, utility, serological, therapeutic strategy, Google Scholar, Support, observation, Web of Science, clinical decision, article, researcher, lack, evaluate, the disease, required, conducted, screened, searched, overcome, addressed, assist, 【제목키워드】 diagnostic, systematic review, Validity, biologic, diagnosis of COVID-19,