The prognosis of the coronavirus disease 2019 (COVID-19) patients is variable and depends on several factors. Current data about the impact of chronic obstructive pulmonary disease (COPD) and smoking on the clinical course of COVID-19 are still controversial. This study evaluated the prevalence and the prognosis of COPD patients and smokers in a cohort of 521 patients admitted to four intermediate Respiratory Intensive Care Units (Puglia, Italy) with respiratory failure due to COVID-19 pneumonia. The prevalence of COPD and current smokers was 14% and 13%, respectively. COPD patients had a higher 30-day all-cause mortality than non-COPD patients. Former smokers compared to never smokers and current smokers had higher 30-day all-cause mortality. COPD patients and former smokers had more comorbidities. This study described the prevalence and the outcomes of COPD patients and smokers in a homogenous cohort of COVID-19 patients. The study showed that the prevalence of COPD and current smokers was not high, suggesting that they were not at increased risk of getting the infection. However, when SARS-CoV-2 infection occurred, COPD patients and former smokers were those with the highest all-cause mortality, which seemed to be mainly related to the presence of comorbidities and not to COPD and smoking itself.
【저자키워드】 Risk factors, Microbiology, Pathogenesis, Signs and symptoms, 【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, COVID-19 pneumonia, Respiratory failure, Prognosis, Pneumonia, SARS-COV-2 infection, Infection, Comorbidities, intensive care unit, outcome, smoking, Italy, COPD, Prevalence, Cohort, Clinical course, Patient, Factors, respiratory, patients, COVID-19 patients, pulmonary disease, Smokers, chronic obstructive pulmonary disease, obstructive pulmonary disease, smoker, not high, increased risk, all-cause mortality, current, highest, described, occurred, evaluated, homogenous, chronic obstructive, Former smoker, had more, presence of comorbidity, 【제목키워드】 Mortality, Comorbidity, Impact, COVID-19 patient,